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Literature summary for 2.7.7.7 extracted from

  • Rey, L.; Sidorova, J.M.; Puget, N.; Boudsocq, F.; Biard, D.S.; Monnat, R.J.; Cazaux, C.; Hoffmann, J.S.
    Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication (2009), Mol. Cell. Biol., 29, 3344-3354.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D115A/E116A catalytically inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MRC-5 cell
-
Homo sapiens
-
U2-OS cell
-
Homo sapiens
-
XP-V XP30RO cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase eta
-
Homo sapiens
Pol eta
-
Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of Pol eta from undamaged human cells affects cell cycle progression (G2/M and proliferative defects) and the rate of cell proliferation and results in increased spontaneous chromosome breaks and common fragile site expression with the activation of ATM-mediated DNA damage checkpoint signaling Homo sapiens
physiological function human DNA polymerase eta modulates susceptibility to skin cancer by promoting translesion DNA synthesis past sunlight-induced cyclobutane pyrimidine dimers Homo sapiens