Literature summary for 2.7.7.7 extracted from

Hidaka, K.; Yamada, M.; Kamiya, H.; Masutani, C.; Harashima, H.; Hanaoka, F.; Nohmi, T.
Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta (2008), DNA Repair, 7, 497-506.

Search for more literature for 2.7.7.7

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-hydroxy-2'-deoxyadenosine 5'-triphosphate + DNAn	DNA polymerase eta incorporates 2-hydroxy-2'-deoxyadenosine 5'-triphosphate opposite template G during DNA synthesis	Homo sapiens	diphosphate + DNAn+1	-	?
8-hydroxy-2'-deoxyguanosine 5'-triphosphate + DNAn	DNA polymerase eta incorporates 8-hydroxy-2'-deoxyguanosine 5'-triphosphate opposite template A and slightly opposite template C during DNA synthesis	Homo sapiens	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase eta	-	Homo sapiens
Poleta	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	Poleta may be involved in induction of various types of mutations through the erroneous and efficient incorporation of oxidized dNTPs into DNA	Homo sapiens

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Release 2023.1 (January 2023)