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Literature summary for 2.7.7.7 extracted from

  • Nishida, M.; Ida, N.; Horio, M.; Takeuchi, T.; Kamisuki, S.; Murata, H.; Kuramochi, K.; Sugawara, F.; Yoshida, H.; Mizushina, Y.
    Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp (2008), Bioorg. Med. Chem., 16, 5115-5122.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
hymenoic acid specific inhibitor of human DNA polymerase lambda, non-competitive inhibition with respect to both the DNA template-primer and the dNTP, i.e trans-4-[(1'E,5'S)-5'-carboxy-1'-methyl-1'-hexenyl]cyclohexanecarboxylic acid, does not influence the activities of the other mammalian pols alpha, gamma, delta, epsilon, eta, iota, and kappa, and also shows no effect even on the activity of pol beta Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase lambda
-
Homo sapiens
Pol lambda
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0917
-
-
Homo sapiens hymenoic acid