Literature summary for 2.7.7.7 extracted from

Sasaki, R.; Suzuki, Y.; Yonezawa, Y.; Ota, Y.; Okamoto, Y.; Demizu, Y.; Huang, P.; Yoshida, H.; Sugimura, K.; Mizushina, Y.
DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells (2008), Cancer Sci., 99, 1040-1048.

Search for more literature for 2.7.7.7

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	DNA polymerase alpha is not inhibited by vitamin K1, vitamin K2, and vitamin K3	Bos taurus
additional information	DNA polymerase isozymes are not inhibited by vitamin K1 and vitamin K2	Homo sapiens
additional information	DNA polymerase beta is not inhibited by vitamin K1, vitamin K2, and vitamin K3	Rattus norvegicus
vitamin K3	more than 80% inhibition of pol gamma at 0.03 mM, does not affect other human DNA polymerase isozymes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic cancer cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
thymus	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Homo sapiens	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	-	Rattus norvegicus	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	-	Bos taurus	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase	-	Homo sapiens
DNA polymerase alpha	-	Bos taurus
DNA polymerase beta	-	Rattus norvegicus
pol alpha	isozyme	Bos taurus
pol beta	-	Rattus norvegicus
pol delta	isozyme	Homo sapiens
POl epsilon	isozyme	Homo sapiens
Pol eta	isozyme	Homo sapiens
Pol gamma	isozyme	Homo sapiens
pol iota	isozyme	Homo sapiens
pol kappa	isozyme	Homo sapiens
Pol lambda	isozyme	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.006	-	isozyme pol gamma, in 50 mM Tris-HCl (pH 7.5) containing 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C	Homo sapiens	vitamin K3

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Release 2023.1 (January 2023)