Literature summary for 2.7.7.7 extracted from

Bailey, M.F.; Van der Schans, E.J.; Millar, D.P.
Dimerization of the Klenow fragment of Escherichia coli DNA polymerase I is linked to its mode of DNA binding (2007), Biochemistry, 46, 8085-8099.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	the Klenow fragment of DNA polymerase I is able to dimerize on a DNA primer/template. Dimerization is favored when the first molecule is bound in the polymerizing mode, but disfavored when it is bound in the editing mode. Self-association of the polymerase may play an important role in coordinating high-fidelity DNA replication	Escherichia coli	diphosphate + DNAn+1	-	?

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Release 2023.1 (January 2023)