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Literature summary for 2.7.7.7 extracted from

  • Ray, A.S.; Feng, J.Y.; Murakami, E.; Chu, C.K.; Schinazi, R.F.; Anderson, K.S.
    Interaction of 2-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma (2007), Antiviral Chem. Chemother., 18, 25-33.
    View publication on PubMed
Search for more literature for 2.7.7.7

Application

Application Comment Organism
medicine mitochondrial toxicity is a limiting factor in the use of some nucleoside reverse transcriptase inhibitors of HIV. DNA polymerase gamma incorporates chain-terminating dioxolane guanosine and 2',3'-dideoxy-2',3'-didehydroguanosine more than 3000fold efficiently than the carboxylic analog carbovir triphosphate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?
additional information (2R,4R)-4-(2-amino-6-oxo-9H-purin-9-yl)-1,3-dioxolan-2-yl-methanol triphosphate and 2',3'-dideoxy-2',3'-didehydroguanoside triphosphate, and carbovir triphosphate are much less efficiently incorporated than the natural deoxynucleoside triphosphate dGTP Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DNA polymerase gamma
-
 Homo sapiens
Pol gamma
-
 Homo sapiens