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Literature summary for 2.7.7.7 extracted from
- Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu (2004), Biochemistry, 43, 13827-13838.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | maximal activity at 8.75 mM | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | in addition to a slow and distributive DNA polymerase activity, Pol mu possesses a weak strand-displacement activity | Homo sapiens | diphosphate + DNAn+1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA polymerase mu | - |
Homo sapiens |
| Pol mu | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
stable for 3 h in an optimized reaction buffer | Homo sapiens |
| 37 | - |
lifetime below 20 min | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 9 | pH 7.2: about 65% of maximal activity, pH 9.0: about 40% of maximal activity | Homo sapiens |
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Release 2023.1 (January 2023)
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