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Literature summary for 2.7.7.7 extracted from

  • Khare, V.; Eckert, K.A.
    The proofreading 3'->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis (2002), Mutat. Res., 510, 45-54.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
RecA exonuclease activity of pol II can be inhibited by the presence of RecA protein and single-strand binding protein Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Escherichia coli
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Herpes simplex virus
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Tequatrovirus T4 exonuclease activity contributes to the avoidance of alkylation mutations diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Herpes simplex virus
-
-
-
Tequatrovirus T4
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism of exonuclease activity Escherichia coli
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism of exonuclease activity Tequatrovirus T4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Escherichia coli diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Herpes simplex virus diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn preferentially removes purines opposite an abasic site Tequatrovirus T4 diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn exonuclease activity associated with the replicative polymerase is contained within the epsilon subunit Escherichia coli diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn exonuclease 3'--5' activity Escherichia coli diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn exonuclease 3'--5' activity Tequatrovirus T4 diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn exonuclease activity utilizes both, ssDNA and melted dsDNA templates, mismatched basepair is preferred over a correct basepair, removes an incorrect base incorporated opposite a template lesion Escherichia coli diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn exonuclease activity utilizes both, ssDNA and melted dsDNA templates, mismatched basepair is preferred over a correct basepair, removes an incorrect base incorporated opposite a template lesion Tequatrovirus T4 diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn exonuclease activity contributes to the avoidance of alkylation mutations Tequatrovirus T4 diphosphate + DNAn+1
-
?