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Literature summary for 2.7.7.7 extracted from

  • Acel, A.; Udashkin, B.E.; Wainberg, M.A.; Faust, E.A.
    Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 integrase (1998), J. Virol., 72, 2062-2071.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and mutant with deletion of 50 amino acids at the C-terminus Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
3'-azido-2',3'-dideoxythymidine 5'-phosphate 50% inhibition at 0.22 mM Human immunodeficiency virus 1
coumermycin A 50% inhibition at 0.05 mM Human immunodeficiency virus 1
pyridoxal 5'-phosphate 50% inhibition at 0.48 mM Human immunodeficiency virus 1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Human immunodeficiency virus 1

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
172100
-
gel filtration and sedimentation experiments Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Human immunodeficiency virus 1 role in DNA gap repair diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Human immunodeficiency virus 1 diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn role in DNA gap repair Human immunodeficiency virus 1 diphosphate + DNAn+1
-
?