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Literature summary for 2.7.7.7 extracted from
- Biochemical characterization of a temperature-sensitive adenovirus DNA polymerase [published erratum appears in Virology 1995 Feb 20;207(1):342] (1994), Virology, 205, 364-370.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| L391F | defective in the in vitro replication initiation and DNA polymerase elongation assays and fails to recognize the viral replication origin if the protein is expressed at 37°C, expression at 32°C results in activities similar to wild-type enzyme | unidentified adenovirus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | unidentified adenovirus | - |
diphosphate + DNAn+1 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| unidentified adenovirus | - |
temerature-sensitive adenoviruses Ad5ts36 and Ad5ts146 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | - |
unidentified adenovirus | diphosphate + DNAn+1 | - |
? | |
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