Literature summary for 2.7.7.7 extracted from

Terry, B.J.; Liu, W.C.; Cianci, C.W.; Proszynski, E.; Fernandes, P.; Bush, K.; Meyers, E.
Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein (1992), J. Antibiot., 45, 286-288.

Search for more literature for 2.7.7.7

Inhibitors

Inhibitors	Comment	Organism	Structure
Oosporein	50% inhibition at 0.7 mM	Escherichia coli
Oosporein	50% inhibition at 0.075 mM	Herpes simplex virus
Oosporein	50% inhibition at 0.61 mM	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	Escherichia coli	-	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	Homo sapiens	-	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	Herpes simplex virus	-	diphosphate + DNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Herpes simplex virus	-	type I DNA polymerase	-
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Herpes simplex virus

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Escherichia coli	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	-	Homo sapiens	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	-	Herpes simplex virus	diphosphate + DNAn+1	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)