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Literature summary for 2.7.7.65 extracted from

  • Aragon, I.M.; Perez-Mendoza, D.; Moscoso, J.A.; Faure, E.; Guery, B.; Gallegos, M.T.; Filloux, A.; Ramos, C.
    Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections (2015), Environ. Microbiol., 17, 4332-4351.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000
-
-
Pseudomonas aeruginosa
76000
-
-
Pseudomonas savastanoi pv. savastanoi

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa S0JAX7
-
-
Pseudomonas aeruginosa PAK S0JAX7
-
-
Pseudomonas savastanoi pv. savastanoi
-
-
-
Pseudomonas savastanoi pv. savastanoi NCPPB 3335
-
-
-

Subunits

Subunits Comment Organism
? x * 76000, calculated Pseudomonas aeruginosa
? x * 76000, calculated Pseudomonas savastanoi pv. savastanoi

Synonyms

Synonyms Comment Organism
DgcP
-
Pseudomonas aeruginosa
DgcP
-
Pseudomonas savastanoi pv. savastanoi

General Information

General Information Comment Organism
physiological function DgcP negatively regulates motility and positively controls biofilm formation. Overexpression of the DgcP gene leads to increased exopolysaccharide production and upregulation of the type VI secretion system, in turn, it represses the type III secretion system, a hallmark of chronic infections and persistence for P.seudomonasaeruginosa. Deletion of the DgcP gene reduces the virulence in a mouse acute lung injury model Pseudomonas aeruginosa
physiological function enzymic activity is dependent on the integrity of its GGDEF domain. Deletion of the dgcP gene shows that DgcP negatively regulates motility and positively controls biofilm formation, the deletion mutant mutant is hypovirulent in olive plants. Overexpression of the gene leads to an enhanced CR-binding phenotype that was accompanied by the formation of wrinkly colonies Pseudomonas savastanoi pv. savastanoi