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Literature summary for 2.7.7.65 extracted from

  • Merritt, J.; Ha, D.; Cowles, K.; Lu, W.; Morales, D.; Rabinowitz, J.; Gitai, Z.; O'Toole, G.
    Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases (2010), mBio, 1, e00183.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.65

Protein Variants

Protein Variants Comment Organism
additional information mutating the critical GGEEF motif to GGAAF results in loss of stimulation of Pel polysaccharide production and biofilm formation Pseudomonas aeruginosa

Localization

Localization Comment Organism GeneOntology No. Textmining
inner membrane SadC and RoeA are differently localized Pseudomonas aeruginosa
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-

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HW69
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-
Pseudomonas aeruginosa Q9I4M8
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Pseudomonas aeruginosa cyclic di-3',5'-guanylate + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
RoeA
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 Pseudomonas aeruginosa
sadC
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 Pseudomonas aeruginosa

General Information

General Information Comment Organism
malfunction deletion mutant shows a biofilm formation defect, a 4fold better swarming motility and a significant reduction of c-di-GMP levels. No correlation between leveles of c-di-GMP and the observed phenotypic output with regard to swarming motilities and extracellular polysaccharide (EPS) is observed Pseudomonas aeruginosa
malfunction deletion mutant shows a biofilm formation defect, a better swarming motility and a significant reduction of c-di-GMP levels. No correlation between leveles of c-di-GMP and the observed phenotypic output with regard to swarming motilities and extracellular polysaccharide (EPS) is observed Pseudomonas aeruginosa
malfunction double mutant containing a deleted sadC and PA1107 gene show a more severe biofilm defect compared to single mutant Pseudomonas aeruginosa
malfunction over-expression of PA1107 leads to enhanced c-di-GMP levels Pseudomonas aeruginosa