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Literature summary for 2.7.7.65 extracted from

  • Tran, N.T.; Den Hengst, C.D.; Gomez-Escribano, J.P.; Buttner, M.J.
    Identification and characterization of CdgB, a diguanylate cyclase involved in developmental processes in Streptomyces coelicolor (2011), J. Bacteriol., 193, 3100-3108.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.65

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Streptomyces coelicolor cyclic di-3',5'-guanylate + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
CdgB
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 Streptomyces coelicolor
cyclic dimeric GMP [c-di-GMP] B
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 Streptomyces coelicolor
diguanylate cyclase
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 Streptomyces coelicolor

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Streptomyces coelicolor

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Streptomyces coelicolor

General Information

General Information Comment Organism
malfunction heterologous expression of cdgB in Escherichia coli results in increased production of extracellular matrix in colonies and enhanced surface attachment of cells in standing liquid cultures. In Streptomyces coelicolor, both overexpression and deletion of cdgB inhibits aerial-mycelium formation, and overexpression also inhibits production of the antibiotic actinorhodin, implicating c-di-GMP in the regulation of developmental processes in Streptomyces Streptomyces coelicolor