Application | Comment | Organism |
---|---|---|
medicine | diguanylate cyclases are interesting targets for new antimicrobial agents with biofilm activity | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
into the pTOPO vector | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a mutant, carrying an adrA mutation resulting in GGDEF -> GGAAF change in AdrA protein catalytic site, is constructed | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sulfathiazole | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Escherichia coli | - |
diphosphate + cyclic di-3',5'-guanylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Escherichia coli | diphosphate + cyclic di-3',5'-guanylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AdrA | - |
Escherichia coli |
DGC | - |
Escherichia coli |
diguanylate cyclase | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | in Gram-negative bacteria production of of cyclic di-3',5'-guanylate, c-di-GMP, is the main trigger for production of extracellular polysaccharides and for biofilm formation | Escherichia coli |