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Literature summary for 2.7.7.60 extracted from

  • Gabrielsen, M.; Bond, C.S.; Hallyburton, I.; Hecht, S.; Bacher, A.; Eisenreich, W.; Rohdich, F.; Hunter, W.N.
    Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis (2004), J. Biol. Chem., 279, 52753-52761.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Agrobacterium tumefaciens
-
Campylobacter jejuni
-
Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method Agrobacterium tumefaciens
hanging drop vapor diffusion method Campylobacter jejuni
hanging drop vapor diffusion method Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41700
-
6 * 41700, crystal structure analysis Campylobacter jejuni
250000
-
analytical ultracentrifugation Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + 2-C-methyl-D-erythritol 4-phosphate Escherichia coli essential enzyme in he mevalonate-independent pathway of isoprenoid biosynthesis diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
CTP + 2-C-methyl-D-erythritol 4-phosphate Agrobacterium tumefaciens essential enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
CTP + 2-C-methyl-D-erythritol 4-phosphate Campylobacter jejuni essential enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?

Organism

Organism UniProt Comment Textmining
Agrobacterium tumefaciens
-
-
-
Campylobacter jejuni
-
-
-
Escherichia coli Q46893
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Agrobacterium tumefaciens
-
Campylobacter jejuni
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + 2-C-methyl-D-erythritol 4-phosphate
-
Agrobacterium tumefaciens diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
CTP + 2-C-methyl-D-erythritol 4-phosphate
-
Campylobacter jejuni diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
CTP + 2-C-methyl-D-erythritol 4-phosphate
-
Escherichia coli diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
CTP + 2-C-methyl-D-erythritol 4-phosphate essential enzyme in he mevalonate-independent pathway of isoprenoid biosynthesis Escherichia coli diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
CTP + 2-C-methyl-D-erythritol 4-phosphate essential enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis Agrobacterium tumefaciens diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
CTP + 2-C-methyl-D-erythritol 4-phosphate essential enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis Campylobacter jejuni diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?

Subunits

Subunits Comment Organism
hexamer
-
Agrobacterium tumefaciens
hexamer 6 * 41700, crystal structure analysis Campylobacter jejuni

Synonyms

Synonyms Comment Organism
IspD
-
Escherichia coli
IspDF bifunctional enzyme catalyzing non-consecutive reactions in the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid precursor biosynthesis Agrobacterium tumefaciens
IspDF bifunctional enzyme catalyzing non-consecutive reactions in the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid precursor biosynthesis Campylobacter jejuni