Literature summary for 2.7.7.6 extracted from

Agarwal, A.; Johnson, A.; Fishwick, C.
Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase (2008), Tetrahedron, 64, 10049-10054.

No PubMed abstract available

Inhibitors

Inhibitors	Comment	Organism
(S)-2-((1-amino-1-oxo-3-phenylpropan-2-ylamino)methyl)-3-(4-amino phenoxy)-5-methoxy phenyl acetate	-	Escherichia coli
(S)-2-((1-amino-1-oxo-3-phenylpropan-2-ylamino)methyl)-3-(4-amino phenoxy)-5-methoxy phenyl acetate	-	Thermus aquaticus
(S)-2-((1-amino-1-oxo-3-phenylpropan-2-ylamino)methyl)-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Escherichia coli
(S)-2-((1-amino-1-oxo-3-phenylpropan-2-ylamino)methyl)-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Thermus aquaticus
(S)-2-((1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)methyl)-3-(4-aminophenoxy)-5-methoxyphenyl acetate	-	Escherichia coli
(S)-2-((1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)methyl)-3-(4-aminophenoxy)-5-methoxyphenyl acetate	-	Thermus aquaticus
(S)-2-((1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)methyl)-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Escherichia coli
(S)-2-((1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)methyl)-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Thermus aquaticus
1,3-dimethoxy-5-(4-nitrophenoxy) benzene	-	Escherichia coli
1,3-dimethoxy-5-(4-nitrophenoxy) benzene	-	Thermus aquaticus
2,4-dimethoxy-6-(4-nitrophenoxy) benzaldehyde	-	Escherichia coli
2,4-dimethoxy-6-(4-nitrophenoxy) benzaldehyde	-	Thermus aquaticus
2-([[(1S)-2-amino-1-(4-hydroxybenzyl)-2-oxoethyl]amino]methyl)-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Escherichia coli
2-([[(1S)-2-amino-1-(4-hydroxybenzyl)-2-oxoethyl]amino]methyl)-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Thermus aquaticus
2-acetyl-3-hydroxy-5-methoxyphenyl acetate	-	Escherichia coli
2-acetyl-3-hydroxy-5-methoxyphenyl acetate	-	Thermus aquaticus
2-acetyl-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Escherichia coli
2-acetyl-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Thermus aquaticus
2-formyl-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Escherichia coli
2-formyl-5-methoxy-3-(4-nitrophenoxy)phenyl acetate	-	Thermus aquaticus
2-hydroxy-4-methoxy-6-(4-nitrophenoxy) benzaldehyde	-	Escherichia coli
2-hydroxy-4-methoxy-6-(4-nitrophenoxy) benzaldehyde	-	Thermus aquaticus
4-[2-([[(1S)-2-amino-1-(4-hydroxybenzyl)ethyl]amino]methyl)-5-methoxy-3-(2-oxopropyl)benzyl]benzaldehyde	-	Escherichia coli
4-[2-([[(1S)-2-amino-1-(4-hydroxybenzyl)ethyl]amino]methyl)-5-methoxy-3-(2-oxopropyl)benzyl]benzaldehyde	-	Thermus aquaticus
additional information	structure-based design of inhibitors with rifampicin as template, inhibitory potencies and binding mechanism via specific hydrogen-bonding sites involving residues Q390, F394, R405, Q567 and Q633, overview	Thermus aquaticus

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Thermus aquaticus	-	-	-

Synonyms

Synonyms	Comment	Organism
RNA polymerase	-	Thermus aquaticus
RNA polymerase	-	Escherichia coli
RNAP	-	Thermus aquaticus
RNAP	-	Escherichia coli