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Literature summary for 2.7.7.6 extracted from

  • Das, A.; Bellofatto, V.
    The non-canonical CTD of RNAP-II is essential for productive RNA synthesis in Trypanosoma brucei (2009), PLoS ONE, 4, e6959.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.6

Protein Variants

Protein Variants Comment Organism
additional information RNAi-targeting of mRNA 39UTR allows regulated depletion of RPB1, mutant RNAP-II containing 1/3 Psi-C-terminal domain is defective in transcription and causes abortive initiation, it is toxic and causes cell death, while a 2/3 Psi-C-terminal domain mutant maintains steady-state transcript levels and still supports cell growth,, overview Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Trypanosoma brucei 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei the PSi-C-terminal domain of large subunit RPB1 is essential for cell survivial and production of both SL RNA and mRNA, the Trypanosoma brucei enzyme lacks conserved heptapeptide sequence motifs found in most other eukaryotes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
 procyclic, tsetse midgut wild-type form, Lister 427
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of polymerase large subunit RPB1 Trypanosoma brucei

Source Tissue

Source Tissue Comment Organism Textmining
29-13 cell stably transfected with plasmid RPB3-SPB Trypanosoma brucei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the PSi-C-terminal domain of large subunit RPB1 is essential for cell survivial and production of both SL RNA and mRNA, the Trypanosoma brucei enzyme lacks conserved heptapeptide sequence motifs found in most other eukaryotes Trypanosoma brucei ?
-
 ?

Subunits

Subunits Comment Organism
More the PSi-C-terminal domain of large subunit RPB1 is essential for cell survivial and production of both SL RNA and mRNA, the Trypanosoma brucei enzyme lacks conserved heptapeptide sequence motifs found in most other eukaryotes Trypanosoma brucei

Synonyms

Synonyms Comment Organism
RNA polymerase II
-
 Trypanosoma brucei
RNAP-II
-
 Trypanosoma brucei

General Information

General Information Comment Organism
physiological function RNAP-II is essential for gene expression in metazoa Trypanosoma brucei