Protein Variants | Comment | Organism |
---|---|---|
additional information | RNAi-targeting of mRNA 39UTR allows regulated depletion of RPB1, mutant RNAP-II containing 1/3 Psi-C-terminal domain is defective in transcription and causes abortive initiation, it is toxic and causes cell death, while a 2/3 Psi-C-terminal domain mutant maintains steady-state transcript levels and still supports cell growth,, overview | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Trypanosoma brucei | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Trypanosoma brucei | the PSi-C-terminal domain of large subunit RPB1 is essential for cell survivial and production of both SL RNA and mRNA, the Trypanosoma brucei enzyme lacks conserved heptapeptide sequence motifs found in most other eukaryotes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
procyclic, tsetse midgut wild-type form, Lister 427 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of polymerase large subunit RPB1 | Trypanosoma brucei |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
29-13 cell | stably transfected with plasmid RPB3-SPB | Trypanosoma brucei | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the PSi-C-terminal domain of large subunit RPB1 is essential for cell survivial and production of both SL RNA and mRNA, the Trypanosoma brucei enzyme lacks conserved heptapeptide sequence motifs found in most other eukaryotes | Trypanosoma brucei | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the PSi-C-terminal domain of large subunit RPB1 is essential for cell survivial and production of both SL RNA and mRNA, the Trypanosoma brucei enzyme lacks conserved heptapeptide sequence motifs found in most other eukaryotes | Trypanosoma brucei |
Synonyms | Comment | Organism |
---|---|---|
RNA polymerase II | - |
Trypanosoma brucei |
RNAP-II | - |
Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
physiological function | RNAP-II is essential for gene expression in metazoa | Trypanosoma brucei |