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Literature summary for 2.7.7.6 extracted from

  • Ayguen, O.; Xu, X.; Liu, Y.; Takahashi, H.; Kong, S.E.; Conaway, R.C.; Conaway, J.W.; Svejstrup, J.Q.
    Direct inhibition of RNA polymerase II transcription by RECQL5 (2009), J. Biol. Chem., 284, 23197-23203.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition of RNA transcription by RECQL5 helicase-deficient point mutant RECQL5D157A, and another human RECQ family helicase, RECQL1 Rattus norvegicus
RECQL5 a DNA helicase of the RECQ family, directly inhibits RNA polymerase II. It RECQL5 inhibits both initiation and elongation in transcription assays reconstituted with highly purified general transcription factors and RNAPII, RECQL5 helicase activity is not required for inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
Rattus norvegicus
Mg2+
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn in vitro transcription reactions with ATP, CTP, GTP, UTP, and oligo(dC)-tailed DNA template derived from pAd-GR220 Rattus norvegicus diphosphate + RNAn+1
-
?

Synonyms

Synonyms Comment Organism
RNA polymerase II
-
Rattus norvegicus
RNAPII
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
assay at Rattus norvegicus