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Literature summary for 2.7.7.6 extracted from

  • Hirata, A.; Murakami, K.S.
    Archaeal RNA polymerase (2009), Curr. Opin. Struct. Biol., 19, 724-731.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Pyrococcus furiosus
additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Saccharolobus solfataricus
additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Saccharolobus shibatae
additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Methanocaldococcus jannaschii
additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Archaeoglobus fulgidus
additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Thermococcus kodakarensis
additional information the Pol II transcription apparatus requires the transcription factors TBP, TFIIB, TFIIEalpha and TFIIS Saccharomyces cerevisiae
additional information the Pol II transcription apparatus requires the transcription factors TBP, TFIIB, TFIIEalpha and TFIIS Schizosaccharomyces pombe

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure determination Pyrococcus furiosus
crystal structure determination Saccharolobus shibatae
crystal structure determination Archaeoglobus fulgidus
crystal structure determination, structure including the A' subunit jaw and clamp head domains and RpoG and Rpo13 subunits Saccharolobus solfataricus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron RNA polymerase is a member of the iron-sulfur cluster protein family Homo sapiens
Iron RNA polymerase is a member of the iron-sulfur cluster protein family Saccharomyces cerevisiae
Iron RNA polymerase is a member of the iron-sulfur cluster protein family Schizosaccharomyces pombe
Iron RNA polymerase is a member of the iron-sulfur cluster protein family and contains one 4Fe-4S cluster binding motif Saccharolobus solfataricus
Iron RNA polymerase is a member of the iron-sulfur cluster protein family and contains one 4Fe-4S cluster binding motif Saccharolobus shibatae
Iron RNA polymerase is a member of the iron-sulfur cluster protein family and contains two 4Fe-4S cluster binding motifs Archaeoglobus fulgidus
Mg2+ the enzyme active site is located on the back wall of the channel, where an essential Mg2+ ion is chelated by three Asp of the absolutely conserved NADFDGD motif in the A' subunit Saccharolobus solfataricus
additional information the Pyrococcus RNA polymerase does not contain iron-sulfur cluster binding motifs Pyrococcus furiosus
additional information the Thermococcus RNA polymerase does not contain iron-sulfur cluster binding motifs Thermococcus kodakarensis

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus
-
-
-
Homo sapiens
-
-
-
Methanocaldococcus jannaschii
-
-
-
Pyrococcus furiosus
-
-
-
Saccharolobus shibatae
-
-
-
Saccharolobus solfataricus
-
-
-
Saccharomyces cerevisiae
-
-
-
Schizosaccharomyces pombe
-
-
-
Thermococcus kodakarensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme active site is located on the back wall of the channel, where an essential Mg2+ ion is chelated by three Asp of the absolutely conserved NADFDGD motif in the A' subunit Saccharolobus solfataricus ?
-
?

Subunits

Subunits Comment Organism
More structure analysis and modeling, overview Saccharolobus shibatae
More structure analysis, overview, the enzyme contains a subunit Rpo13 located at a groove between the H subunit and the clamp head domain of the A' subunit, model ing including the A' subunit jaw and clamp head domains and RpoG and Rpo13, overview Saccharolobus solfataricus
More the enzyme lacks the Rpb8 and Rpo13 subunits Pyrococcus furiosus

Synonyms

Synonyms Comment Organism
More RNA polymerase is a member of the iron-sulfur cluster protein family Homo sapiens
More RNA polymerase is a member of the iron-sulfur cluster protein family Saccharomyces cerevisiae
More RNA polymerase is a member of the iron-sulfur cluster protein family Schizosaccharomyces pombe
More RNA polymerase is a member of the iron-sulfur cluster protein family Saccharolobus solfataricus
More RNA polymerase is a member of the iron-sulfur cluster protein family Saccharolobus shibatae
More RNA polymerase is a member of the iron-sulfur cluster protein family Methanocaldococcus jannaschii
More RNA polymerase is a member of the iron-sulfur cluster protein family Archaeoglobus fulgidus
Pol II
-
Saccharomyces cerevisiae
Pol II
-
Schizosaccharomyces pombe
RNA polymerase
-
Homo sapiens
RNA polymerase
-
Saccharomyces cerevisiae
RNA polymerase
-
Pyrococcus furiosus
RNA polymerase
-
Schizosaccharomyces pombe
RNA polymerase
-
Saccharolobus solfataricus
RNA polymerase
-
Saccharolobus shibatae
RNA polymerase
-
Methanocaldococcus jannaschii
RNA polymerase
-
Archaeoglobus fulgidus
RNA polymerase
-
Thermococcus kodakarensis
RNAP
-
Homo sapiens
RNAP
-
Saccharomyces cerevisiae
RNAP
-
Pyrococcus furiosus
RNAP
-
Schizosaccharomyces pombe
RNAP
-
Saccharolobus solfataricus
RNAP
-
Saccharolobus shibatae
RNAP
-
Methanocaldococcus jannaschii
RNAP
-
Archaeoglobus fulgidus
RNAP
-
Thermococcus kodakarensis

Cofactor

Cofactor Comment Organism Structure
Fe-S cluster with 4Fe-4S cluster-binding motif Saccharolobus solfataricus