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BRENDA support

Literature summary for 2.7.7.6 extracted from

  • Kruhlak, M.; Crouch, E.E.; Orlov, M.; Montano, C.; Gorski, S.A.; Nussenzweig, A.; Misteli, T.; Phair, R.D.; Casellas, R.
    The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks (2007), Nature, 447, 730-734.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
etoposide treatment with 0.02 mM etoposide leads to a transient inhibition of rRNA synthesis Mus musculus
additional information gamma irradiation leads to a transient inhibition of rRNA synthesis, but Pol I transcription is not blocked by DNA damage itself, but by the action of DNA repair enzymes Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
Mus musculus diphosphate + RNAn+1
-
?

Synonyms

Synonyms Comment Organism
Pol I
-
Mus musculus
RNA polymerase I
-
Mus musculus