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Literature summary for 2.7.7.6 extracted from

  • Callaci, S.; Heyduk, T.
    Conformation and DNA binding properties of a single-stranded DNA binding region of sigma 70 subunit from Escherichia coli RNA polymerase are modulated by an interaction with the core enzyme (1998), Biochemistry, 37, 3312-3320.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn the enzyme requires DNA as template Escherichia coli diphosphate + RNAn+1
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Subunits

Subunits Comment Organism
More binding of the sigma70 subunit to the core enzyme induces conformational changes in a single-stranded DNA binding region of the protein. As a consequence of these conformational changes, sigma70 subunit gains the specificity for the nontemplate strand of the melted region in the open complex Escherichia coli