Literature summary for 2.7.7.49 extracted from

Chaves Valadao, A.L.; Abreu, C.M.; Dias, J.Z.; Arantes, P.; Verli, H.; Tanuri, A.; de Aguiar, R.S.
Natural plant alkaloid (emetine) inhibits HIV-1 replication by interfering with reverse transcriptase activity (2015), Molecules, 20, 11474-11489.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking of inhibitor emetine	Human immunodeficiency virus 1

Inhibitors

Inhibitors	Comment	Organism	Structure
emetine	plant alkaloid isolated from Psychotria ipecacuanha. Reverse transcriptase is blocked in the presence of emetine both both in in vitro reactions with isolated enzyme and intravirion, reaching 80% of reduction in HIV-1 infection, with low cytotoxic effect. Emetine also blocks HIV-1 infection of reverse transcriptase M184V mutants	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

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Release 2023.1 (January 2023)