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Literature summary for 2.7.7.49 extracted from

  • Nguyen, L.A.; Domaoal, R.A.; Kennedy, E.M.; Kim, D.H.; Schinazi, R.F.; Kim, B.
    Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template (2015), Antiviral Res., 115, 75-82.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information binding affinity Kd of HIV-1 reverse transcriptase for non-canonical rNTPs is 1.4- to 43fold lower, and the rNTP rate of incorporation is 15- to 1551fold slower than for dNTP, suggesting that reverse transcriptase is more selective for incorporation of dNTPs rather than rNTPs. HIV-1 reverse transcriptase selectivity for dNTP versus rNTP is the lowest for ATP Human immunodeficiency virus 1 ?
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