Literature summary for 2.7.7.49 extracted from

Goldschmidt, V.; Didierjean, J.; Ehresmann, B.; Ehresmann, C.; Isel, C.; Marquet, R.
Mg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance (2006), Nucleic Acids Res., 34, 42-52.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	reverse transcription of poly(rA) in the presence of 3.5 mM ATP, initial velocity smoothly decreases between 3 and 7 mM MgCl2 and sharply drops below 3 mM. Addition of 3.5 mM ATP shifts the optimal MgCl2 concentration from 1 to 3 mM. At low Mg2+ concentration, reverse transcription of a natural template strongly increases despite a dramatically reduced intrinsic polymerase activity under such conditions. Low Mg2+ concentrations affect the RNA stability and indirectly decreased its degradation by the RNase H activity	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Synonyms

Synonyms	Comment	Organism
HIV-1 RT	-	Human immunodeficiency virus 1

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Release 2023.1 (January 2023)