Literature summary for 2.7.7.49 extracted from

Jamburuthugoda, V.K.; Guo, D.; Wedekind, J.E.; Kim, B.
Kinetic evidence for interaction of Human immunodeficiency virus type 1 reverse transcriptase with the 3'-OH of the incoming dTTP substrate (2005), Biochemistry, 44, 10635-10643.

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Protein Variants

Protein Variants	Comment	Organism
Q151N	reduced dNTP binding affinity, mutant loses the interaction with the 3'-OH of the incoming dTTP, mutant enzyme binds to AZTTP 12 times more tightly than to dTTP	Human immunodeficiency virus 1
V148I	reduced dNTP binding affinity, mutation V148I disrupts positioning of Q151 for interaction with the 3'-OH of the incoming dTTP, mutant enzyme binds to AZTTP 18 times more tightly than to dTTP	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Human immunodeficiency virus 1

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Release 2023.1 (January 2023)