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Literature summary for 2.7.7.49 extracted from

  • Chu, S.C.; Hsieh, Y.S.; Lin, J.Y.
    Inhibitory effects of flavonoids on Moloney murine leukemia virus reverse transcriptase activity (1992), J. Nat. Prod., 55, 179--183.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(+)-catechin
-
 Moloney murine leukemia virus
(+)-taxifolin
-
 Moloney murine leukemia virus
(-)-epicatechin
-
 Moloney murine leukemia virus
fisetin
-
 Moloney murine leukemia virus
flavanonol low inhibition Moloney murine leukemia virus
flavone low inhibition Moloney murine leukemia virus
flavonol
-
 Moloney murine leukemia virus
kaempferol
-
 Moloney murine leukemia virus
additional information simultaneous presence of free hydroxyl groups at position 3 and 4' enhance the reverse transcriptase inhibitory activity. Replacement of the 3-hydroxyl group with a monosaccharide or of the 4'-hydroxyl group with a Me group reduces inhibitory activity. The double bond at position 2 and 3 of the flavonoid‘s pyrone ring is not essential for inhibiting reverse transcriptase activity Moloney murine leukemia virus
morin
-
 Moloney murine leukemia virus
myricetin
-
 Moloney murine leukemia virus
quercetin
-
 Moloney murine leukemia virus

Organism

Organism UniProt Comment Textmining
Moloney murine leukemia virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Moloney murine leukemia virus diphosphate + DNAn+1
-
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