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Literature summary for 2.7.7.3 extracted from

  • Takahashi, H.; Inagaki, E.; Fujimoto, Y.; Kuroishi, C.; Nodake, Y.; Nakamura, Y.; Arisaka, F.; Yutani, K.; Kuramitsu, S.; Yokoyama, S.; Yamamoto, M.; Miyano, M.; Tahirov, T.H.
    Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus (2004), Acta Crystallogr. Sect. D, 60, 97-104.
    View publication on PubMed
Search for more literature for 2.7.7.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) Thermus thermophilus

Crystallization (Commentary)

Crystallization (Comment) Organism
oil batch method Thermus thermophilus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17700
-
 6 * 17700, crystal structure analysis, analytical ultracentrifugation data of the native enzyme suggests an equilibrium of two trimers and one hexamer in solution Thermus thermophilus
17800
-
 6 * 17800 Escherichia coli
67000
-
 analytical ultracentrifugation Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pantetheine 4'-phosphate Thermus thermophilus rate-limiting penultimate step in coenzyme A biosynthesis diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate Escherichia coli rate-limiting penultimate step in coenzyme A biosynthesis diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate Thermus thermophilus HB8 / ATCC 27634 / DSM 579 rate-limiting penultimate step in coenzyme A biosynthesis diphosphate + 3'-dephospho-CoA
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Thermus thermophilus
-
-
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Thermus thermophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pantetheine 4'-phosphate
-
 Thermus thermophilus diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate
-
 Escherichia coli diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate rate-limiting penultimate step in coenzyme A biosynthesis Thermus thermophilus diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate rate-limiting penultimate step in coenzyme A biosynthesis Escherichia coli diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate
-
 Thermus thermophilus HB8 / ATCC 27634 / DSM 579 diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate rate-limiting penultimate step in coenzyme A biosynthesis Thermus thermophilus HB8 / ATCC 27634 / DSM 579 diphosphate + 3'-dephospho-CoA
-
 r

Subunits

Subunits Comment Organism
hexamer 6 * 17700, crystal structure analysis, analytical ultracentrifugation data of the native enzyme suggests an equilibrium of two trimers and one hexamer in solution Thermus thermophilus
hexamer 6 * 17800 Escherichia coli