Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide | inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity | Pseudomonas aeruginosa | |
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide | inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity | Pseudomonas aeruginosa | |
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylfuran-2-sulfonamide | inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | Q9HU22 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose | ordered bi-bi mechanism | Pseudomonas aeruginosa |
Synonyms | Comment | Organism |
---|---|---|
RmlA | - |
Pseudomonas aeruginosa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000073 | - |
pH not specified in the publication, temperature not specified in the publication | Pseudomonas aeruginosa | N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide | |
0.000105 | - |
pH not specified in the publication, temperature not specified in the publication | Pseudomonas aeruginosa | N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylfuran-2-sulfonamide | |
0.000175 | - |
pH not specified in the publication, temperature not specified in the publication | Pseudomonas aeruginosa | N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide |