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Literature summary for 2.7.7.24 extracted from

  • Alphey, M.S.; Pirrie, L.; Torrie, L.S.; Boulkeroua, W.A.; Gardiner, M.; Sarkar, A.; Maringer, M.; Oehlmann, W.; Brenk, R.; Scherman, M.S.; McNeil, M.; Rejzek, M.; Field, R.A.; Singh, M.; Gray, D.; Westwood, N.J.; Naismith, J.H.
    Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa (2013), ACS Chem. Biol., 8, 387-396.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity Pseudomonas aeruginosa
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity Pseudomonas aeruginosa
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylfuran-2-sulfonamide inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HU22
-
-

Reaction

Reaction Comment Organism Reaction ID
dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose ordered bi-bi mechanism Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
RmlA
-
Pseudomonas aeruginosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000073
-
pH not specified in the publication, temperature not specified in the publication Pseudomonas aeruginosa N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide
0.000105
-
pH not specified in the publication, temperature not specified in the publication Pseudomonas aeruginosa N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylfuran-2-sulfonamide
0.000175
-
pH not specified in the publication, temperature not specified in the publication Pseudomonas aeruginosa N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide