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Literature summary for 2.7.7.22 extracted from

  • Cottrell, T.R.; Griffith, C.L.; Liu, H.; Nenninger, A.A.; Doering, T.L.
    The pathogenic fungus Cryptococcus neoformans expresses two functional GDP-mannose transporters with distinct expression patterns and roles in capsule synthesis (2007), Eukaryot. Cell, 6, 776-785.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Cryptococcus neoformans 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP + alpha-D-mannose 1-phosphate Cryptococcus neoformans
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 phosphate + GDP-mannose
-
 ?
additional information Cryptococcus neoformans GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
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 serotype D strains JEC21
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP + alpha-D-mannose 1-phosphate
-
 Cryptococcus neoformans phosphate + GDP-mannose
-
 ?
additional information GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity Cryptococcus neoformans ?
-
 ?

Synonyms

Synonyms Comment Organism
GDP-D-mannose pyrophosphorylase
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 Cryptococcus neoformans