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Literature summary for 2.7.7.19 extracted from
- Purification and characterization of a poly(A) polymerase from beef liver nuclei (1980), J. Biochem., 88, 337-348.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Bentonite | - |
Bos taurus | |
| diphosphate | - |
Bos taurus |  |
| heparin | - |
Bos taurus | |
| Polyvinyl sulfate | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
short poly(A) | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Bos taurus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | completely inactive in presence of Mg2+ | Bos taurus | |
| Mn2+ | required | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
glycerol density gradient centrifugation | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin short poly(A) | - |
Bos taurus | ? | - |
? | |
| ATP + RNA | highly specific for ATP | Bos taurus | diphosphate + RNA(A)n | - |
? | |
| ATP + RNA | no primer: mixture of tRNA | Bos taurus | diphosphate + RNA(A)n | - |
? | |
| ATP + RNA | primer: short poly(U) | Bos taurus | diphosphate + RNA(A)n | - |
? | |
| ATP + RNA | primer required | Bos taurus | diphosphate + RNA(A)n | - |
? | |
| ATP + RNA | primer: poly(G,U) | Bos taurus | diphosphate + RNA(A)n | - |
? | |
| ATP + RNA | no primer: phage RNA | Bos taurus | diphosphate + RNA(A)n | - |
? | |
| ATP + RNA | poly(A) is the most effective primer | Bos taurus | diphosphate + RNA(A)n | - |
? | |
| ATP + RNA | no primer: poly(G) | Bos taurus | diphosphate + RNA(A)n | - |
? | |
| ATP + RNA | no primer: poly(C) | Bos taurus | diphosphate + RNA(A)n | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 57000, SDS-PAGE | Bos taurus |
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Release 2023.1 (January 2023)
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