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Literature summary for 2.7.7.13 extracted from

  • Kempinski, C.F.; Haffar, R.; Barth, C.
    Toward the mechanism of NH4+ sensitivity mediated by Arabidopsis GDP-mannose pyrophosphorylase (2011), Plant Cell Environ., 34, 847-858.
    View publication on PubMed
Search for more literature for 2.7.7.13

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
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Arabidopsis thaliana Col-0
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Source Tissue

Source Tissue Comment Organism Textmining
root
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 Arabidopsis thaliana
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Synonyms

Synonyms Comment Organism
GDP-mannose pyrophosphorylase
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 Arabidopsis thaliana
GMPase
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 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction the ascorbic acid-deficient Arabidopsis thaliana mutant vtc1-1 is defective in GDP-mannose pyrophosphorylase and exhibits conditional hypersensitivity to ammonium, a phenomenon that is independent of ascorbic acid deficiency. Defective N-glycosylation in vtc1-1 contributes to cell wall, membrane and cell cycle defects, resulting in root growth inhibition in the presence of NH4+, GDP-mannose deficiency does not generally lead to and is not the primary cause of NH4+ sensitivity. GDP-mannose deficiency results in an up-regulation of ER stress genes, enhanced programmed cell death and defective cell cycle proliferation in vtc1-1 triggered by NH4+, overview. Root development in the presence of NH4+ is fully recovered in vtc1-1 containing one wild-type copy of VTC1 Arabidopsis thaliana