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Literature summary for 2.7.7.1 extracted from
- Modulation of cytotoxicity of benzamide riboside by expression of NMN adenylyltransferase (2002), Curr. Med. Chem., 9, 749-758.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.055 | - |
tiazofurin | YGR010W | Saccharomyces cerevisiae |  |
| 0.108 | - |
ATP | YGR010W | Saccharomyces cerevisiae | |
| 0.11 | - |
ATP | YLR328W | Saccharomyces cerevisiae | |
| 0.153 | - |
NMN | YGR010W | Saccharomyces cerevisiae | |
| 0.19 | - |
NMN | YLR328W | Saccharomyces cerevisiae | |
| 1.18 | - |
ATP | tiazofurin as second substrate, YGR010W | Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Mammalia | 5634 | - |
| nucleus | chromatin-associated | Homo sapiens | 5634 | - |
| nucleus | chromatin-associated | Saccharomyces cerevisiae | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Saccharomyces cerevisiae | |
| Co2+ | - |
Homo sapiens | |
| Co2+ | - |
Saccharomyces cerevisiae | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Saccharomyces cerevisiae | |
| Ni2+ | - |
Homo sapiens | |
| Ni2+ | - |
Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mammalia | - |
- |
- |
| Mus musculus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-16 cell | - |
Mus musculus | - |
| colonic cancer cell line | colon 38 | Mus musculus | - |
| erythrocyte | - |
Homo sapiens | - |
| Friend erythroleukemia cell line | - |
Mus musculus | - |
| L-1210 cell | - |
Mus musculus | - |
| Lewis lung carcinoma cell line | - |
Mus musculus | - |
| M5076 cell | - |
Mus musculus | - |
| P-388 cell | Tiazofurin resistant | Mus musculus | - |
| placenta | - |
Mammalia | - |
| placenta | - |
Homo sapiens | - |
| testis | - |
Mammalia | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.112 | - |
tiazofurin as substrate, YGR010W | Saccharomyces cerevisiae |
| 13.8 | - |
gene product YGR010W | Saccharomyces cerevisiae |
| 74.2 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tiazofurin + ATP | - |
Homo sapiens | tiazofurin adenine dinucleotide + diphosphate | - |
? | |
| tiazofurin + ATP | YLR010W | Saccharomyces cerevisiae | tiazofurin adenine dinucleotide + diphosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | YGR010W | Saccharomyces cerevisiae |
| 7.8 | 8.4 | YLR328W | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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