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Literature summary for 2.7.4.8 extracted from

  • Gonzalez-Gutierrez, G.; Miranda-Laferte, E.; Nothmann, D.; Schmidt, S.; Neely, A.; Hidalgo, P.
    The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating (2008), Proc. Natl. Acad. Sci. USA, 105, 14198-14203.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.8

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of Cavbeta1b in Xenopus laevis oocytes in inclusion bodies Rattus norvegicus
overexpression of Cavbeta2a in Xenopus laevis oocytes in inclusion bodies Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the voltage-gated calcium channel beta1b contains a conserved guanylate kinase domain, which is alone recapitulating calcium channel beta-subunit CaVbeta-mediated modulation of channel activation facilitating inactivation of the voltage-gated channel. CaVbeta can switch the inactivation phenotype conferred to CaV2.3 from slow to fast after posttranslational modifications during channel biogenesis, modulation mechanism, overview ?
-
 ?
additional information Rattus norvegicus the voltage-gated calcium channel beta2a contains a conserved guanylate kinase domain, which is alone recapitulating calcium channel beta-subunit CaVbeta-mediated modulation of channel activation inhibiting inactivation of the voltage-gated channel. CaVbeta can switch the inactivation phenotype conferred to CaV2.3 from slow to fast after posttranslational modifications during channel biogenesis, modulation mechanism, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Q8VGC3 Cavbeta2a
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Renatured (Commentary)

Renatured (Comment) Organism
recombinant Cavbeta1b after overexpression in inclusion bodies in Xenopus laevis oocytes Rattus norvegicus
recombinant Cavbeta2a from inclusion bodies after overexpression in Xenopus laevis oocytes Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the voltage-gated calcium channel beta1b contains a conserved guanylate kinase domain, which is alone recapitulating calcium channel beta-subunit CaVbeta-mediated modulation of channel activation facilitating inactivation of the voltage-gated channel. CaVbeta can switch the inactivation phenotype conferred to CaV2.3 from slow to fast after posttranslational modifications during channel biogenesis, modulation mechanism, overview Rattus norvegicus ?
-
 ?
additional information the voltage-gated calcium channel beta2a contains a conserved guanylate kinase domain, which is alone recapitulating calcium channel beta-subunit CaVbeta-mediated modulation of channel activation inhibiting inactivation of the voltage-gated channel. CaVbeta can switch the inactivation phenotype conferred to CaV2.3 from slow to fast after posttranslational modifications during channel biogenesis, modulation mechanism, overview Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
dimer the recombinant refolded CaVbeta2a-GK is essentially a dimer Rattus norvegicus
monomer or dimer the recombinant and refolded CaVbeta1b-GK is a mixture of dimers and monomers Rattus norvegicus

Synonyms

Synonyms Comment Organism
Cavbeta1b
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 Rattus norvegicus
Cavbeta2a
-
 Rattus norvegicus
voltage-gated calcium channel beta1b
-
 Rattus norvegicus
voltage-gated calcium channel beta2a
-
 Rattus norvegicus