Literature summary for 2.7.4.8 extracted from

El Omari, K.; Dhaliwal, B.; Lockyer, M.; Charles, I.; Hawkins, A.R.; Stammers, D.K.
Structure of Staphylococcus aureus guanylate monophosphate kinase (2006), Acta Crystallogr. Sect. F, F62, 949-953.

Search for more literature for 2.7.4.8

Crystallization (Commentary)

Crystallization (Comment)	Organism
Crystals grown in 20% PEG 3350, 0.2 M LiSO4 and 0.1 M Tris-HCl pH 8.	Staphylococcus aureus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
24000	-	guanylate monophosphate kinase	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dGMP + ATP	Catalyses reversible phosphoryl transfer from a nucleotide donor to a nucleotide acceptor. Phosphorylation of (d)GMP to (d)GDP using ATP as phosphoryl donor. Guanylate monophosphate kinases are involved in the synthesis of nucleotide precursors, they indirectly modulate the synthesis of DNA and RNA.	Staphylococcus aureus	dGDP + ADP	-	r
GMP + ATP	Catalyses reversible phosphoryl transfer from a nucleotide donor to a nucleotide acceptor. Phosphorylation of (d)GMP to (d)GDP using ATP as phosphoryl donor. Guanylate monophosphate kinases are involved in the synthesis of nucleotide precursors, they indirectly modulate the synthesis of DNA and RNA.	Staphylococcus aureus	GDP + ADP	-	r

Subunits

Subunits	Comment	Organism
dimer	One of the two SaGMK dimers within the crystal asymmetric unit has two monomers in different conformations: an open form with a bound sulfate ion (mimicking the beta-phosphate of ATP) and a closed form with bound GMP and sulfate ion. Each monomer is bound through its P-loop to a sulfate ion.	Staphylococcus aureus

Synonyms

Synonyms	Comment	Organism
guanylate monophosphate kinase	-	Staphylococcus aureus
Staphylococcus aureus guanylate monophosphate kinase	-	Staphylococcus aureus

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Release 2023.1 (January 2023)