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Literature summary for 2.7.4.8 extracted from
- Phosphorylation of the antiviral precursor 9-(1,3-dihydroxy-2-propoxymethyl)guanine monophosphate by guanylate kinase isozymes (1984), J. Biol. Chem., 259, 12346-12349.
General Stability
| General Stability | Organism |
|---|---|
| bovine serum albumin stabilizes during purification | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate | - |
Homo sapiens |  |
| 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic parameters of several substrates for 4 isoenzymes | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 4 isoenzymes purified by a method that includes GMP agarose chromatography and isoelectric focusing | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + dGMP | - |
Homo sapiens | ADP + dGDP | - |
r | |
| ATP + GMP | - |
Homo sapiens | ADP + GDP | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.043 | - |
9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate | pH 7.5, isoenzyme 4 | Homo sapiens | |
| 0.052 | - |
9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate | pH 7.5, isoenzyme 4 | Homo sapiens | |
| 0.06 | - |
9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate | pH 7.5, isoenzyme 1 | Homo sapiens | |
| 0.067 | - |
9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate | pH 7.5, isoenzyme 2 | Homo sapiens | |
| 0.45 | - |
9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate | pH 7.5, isoenzyme 4 | Homo sapiens | |
| 0.65 | - |
9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate | pH 7.5, isoenzyme 2 | Homo sapiens | |
| 0.67 | - |
9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate | pH 7.5, isoenzyme 3 | Homo sapiens | |
| 0.84 | - |
9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate | pH 7.5, isoenzyme 1 | Homo sapiens | |
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