Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AMP | - |
Mus musculus | 2 ADP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adenylate kinase 2 | - |
Mus musculus |
AK2 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | adenylate kinase 2 is markedly induced during adipocyte and B cell differentiation | up |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of adenylate kinase 2 (AK2) by RNAi impairs adiponectin secretion in 3T3-L1 adipocytes, immunoglobulin M secretion in BCL1 cells, and the induction of the unfolded protein response during differentiation of both cell types. Depletion of AK2 results in changes in adipocyte energy homeostasis, but these effects do not detectably impair key adipocyte properties such as mitochondrial biogenesis and triglyceride storage | Mus musculus |
metabolism | adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response | Mus musculus |