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Literature summary for 2.7.4.22 extracted from

  • Sakamoto, H.; Landais, S.; Evrin, C.; Laurent-Winter, C.; Barzu, O.; Kelln, R.A.
    Structure-function relationships of UMP kinases from pyrH mutants of Gram-negative bacteria (2004), Microbiology, 150, 2153-2159.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
GTP
-
Salmonella enterica subsp. enterica serovar Typhimurium

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli
-
Salmonella enterica subsp. enterica serovar Typhimurium

Protein Variants

Protein Variants Comment Organism
A122T activity decreased to 26% of the wild-type Salmonella enterica subsp. enterica serovar Typhimurium
D201G activity decreased to 16% of the wild-type, significant loss of sensitivity to activation by GTP Salmonella enterica subsp. enterica serovar Typhimurium
D201N/E241D activity decreased to 1% of the wild-type Salmonella enterica subsp. enterica serovar Typhimurium
G232D resistance to heat denaturation is altered, catalytic avtivity is reduced to 17% of the wild-type Escherichia coli
R11H lowered catalytic activity, 45% of the wild-type, resistance to heat denaturation is impaired Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
UTP
-
Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UMP Escherichia coli
-
ADP + UDP
-
?
ATP + UMP Salmonella enterica subsp. enterica serovar Typhimurium
-
ADP + UDP
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A7E9
-
-
Escherichia coli P0A7E9 wild type
-
Escherichia coli P0A7E9 strain KUR1244/K12 pyrH (high dose)
-
Escherichia coli P0A7E9 strain KUR1244/K12 pyrH (low dose)
-
Salmonella enterica subsp. enterica serovar Typhimurium P65933 serovar Typhimurum
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli
-
Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.003
-
-
Escherichia coli
0.034
-
-
Escherichia coli
0.1
-
-
Escherichia coli
2.4
-
-
Escherichia coli
7.2
-
mutant D201G Salmonella enterica subsp. enterica serovar Typhimurium
50
-
wild-type Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UMP
-
Escherichia coli ADP + UDP
-
?
ATP + UMP
-
Salmonella enterica subsp. enterica serovar Typhimurium ADP + UDP
-
?
ATP + UMP 30°C, pH 7.4 Escherichia coli ADP + UDP
-
?
ATP + UMP 30°C, pH 7.4 Salmonella enterica subsp. enterica serovar Typhimurium ADP + UDP
-
?

Synonyms

Synonyms Comment Organism
UMP kinase
-
Escherichia coli
UMP kinase
-
Salmonella enterica subsp. enterica serovar Typhimurium
uridine monophosphate kinase
-
Escherichia coli
uridine monophosphate kinase
-
Salmonella enterica subsp. enterica serovar Typhimurium

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
Tm of mutant R11H Escherichia coli
57
-
Tm of mutant G232D Escherichia coli
63
-
Tm of the wild-type Escherichia coli
63
-
Tm of wild-type and mutant D201G Salmonella enterica subsp. enterica serovar Typhimurium