Application | Comment | Organism |
---|---|---|
drug development | UMP kinase may be a potential antimicrobial target | Pyrococcus furiosus |
Cloned (Comment) | Organism |
---|---|
- |
Pyrococcus furiosus |
Crystallization (Comment) | Organism |
---|---|
resolved at 2.4 A resolution. Complexed with AMP-PNP, resolved at 3 A resolution. Complexed with AMP-PNP and UMP, resolved at 2.55 A resolution | Pyrococcus furiosus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | the crystal structure contains two bound Mg ions, of which one helps stabilize the transition state | Pyrococcus furiosus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UMP | Pyrococcus furiosus | - |
ADP + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pyrococcus furiosus | Q8U122 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Pyrococcus furiosus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UMP | - |
Pyrococcus furiosus | ADP + UDP | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | alpha6, organized as a dimer of trimers, crystal structure | Pyrococcus furiosus |
Synonyms | Comment | Organism |
---|---|---|
UMP kinase | - |
Pyrococcus furiosus |
UMPK | - |
Pyrococcus furiosus |