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Literature summary for 2.7.4.22 extracted from

  • Marco-Marํn, C.; Gil-Ortiz, F.; Rubio, V.
    The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis (2005), J. Mol. Biol., 352, 438-454.
    View publication on PubMed

Application

Application Comment Organism
drug development UMP kinase may be a potential antimicrobial target Pyrococcus furiosus

Cloned(Commentary)

Cloned (Comment) Organism
-
Pyrococcus furiosus

Crystallization (Commentary)

Crystallization (Comment) Organism
resolved at 2.4 A resolution. Complexed with AMP-PNP, resolved at 3 A resolution. Complexed with AMP-PNP and UMP, resolved at 2.55 A resolution Pyrococcus furiosus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ the crystal structure contains two bound Mg ions, of which one helps stabilize the transition state Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UMP Pyrococcus furiosus
-
ADP + UDP
-
?

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus Q8U122
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Pyrococcus furiosus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UMP
-
Pyrococcus furiosus ADP + UDP
-
?

Subunits

Subunits Comment Organism
hexamer alpha6, organized as a dimer of trimers, crystal structure Pyrococcus furiosus

Synonyms

Synonyms Comment Organism
UMP kinase
-
Pyrococcus furiosus
UMPK
-
Pyrococcus furiosus