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Literature summary for 2.7.4.21 extracted from
- The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export (2019), J. Biol. Chem., 294, 11597-11608 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q92551 | - |
- |
| Homo sapiens | Q9UHH9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HCT-116 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IP6K1 | - |
Homo sapiens |
| IP6K2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | IP6K1/2-knockout cells have nondetectable levels of the IP6-derived 5-diphosphoinositol pentakisphosphate and bisdiphosphoinositol tetrakisphosphate and also exhibit reduced synthesis of the 5-diphosphoinositol pentakisphosphate-derived diphosphoinositol tetrakisphosphate. Knockout cells contain increased amounts of ATP, and elevated levels of free intracellular phosphate. Phosphate import and export of phosphate are decreased in the knockout cells | Homo sapiens |
| physiological function | inositol hexakisphosphate kinase (IP6K1) and IP6K2 together control inositol pyrophosphate metabolism and thereby physiologically regulate phosphate export and other aspects of mammalian cellular phosphate homeostasis | Homo sapiens |
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Release 2023.1 (January 2023)
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