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Literature summary for 2.7.4.21 extracted from

  • Rajasekaran, S.S.; Kim, J.; Gaboardi, G.C.; Gromada, J.; Shears, S.B.; Dos Santos, K.T.; Nolasco, E.L.; Ferreira, S.S.; Illies, C.; Koehler, M.; Gu, C.; Ryu, S.H.; Martins, J.O.; Dare, E.; Barker, C.J.; Berggren, P.O.
    Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic beta-cells (2018), Cell. Signal., 46, 120-128 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.21

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate Mus musculus
-
 ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92551
-
-
Mus musculus Q6PD10
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic beta cell
-
 Mus musculus
-
pancreatic beta cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase 1
-
 Mus musculus
inositol hexakisphosphate kinase 1
-
 Homo sapiens
IP6K1
-
 Mus musculus
IP6K1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction RNAi mediated knock down of the IP6K1 isoform inhibits both glucose-mediated increase in diphosphoinositol pentakisphosphate and first phase insulin secretion Mus musculus
physiological function inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic beta-cells Mus musculus
physiological function islets from patients with T2D (a multifactorial, polygenetic disease) show impaired ATP generation in response to nutrients, in association with mitochondrial dysfunction. The regulation of IP6K1 activity is likely to be a vulnerable point in early disease development Homo sapiens
physiological function the enzyme (IP6K1) integrates glucose metabolism and insulin exocytosis Mus musculus
physiological function the enzyme (IP6K1) integrates glucose metabolism and insulin exocytosis Homo sapiens