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Literature summary for 2.7.4.21 extracted from

  • Desai, M.; Rangarajan, P.; Donahue, J.L.; Williams, S.P.; Land, E.S.; Mandal, M.K.; Phillippy, B.Q.; Perera, I.Y.; Raboy, V.; Gillaspy, G.E.
    Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants (2014), Plant J., 80, 642-653.
    View publication on PubMed
Search for more literature for 2.7.4.21

Cloned(Commentary)

Cloned (Comment) Organism
gene vip1, phylogenetic analysis, AtVip1 restores InsP7 synthesis in a Saccharomyces cerevisiae kcs1 mutant Arabidopsis thaliana
gene vip2, phylogenetic analysis, AtVip2 restores InsP7 synthesis in a Saccharomyces cerevisiae kcs1 mutant Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
D292A site-directed mutagenesis, inactive mutant Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate Arabidopsis thaliana
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate Arabidopsis thaliana Col-0
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate Arabidopsis thaliana
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate Arabidopsis thaliana Col-0
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate Arabidopsis thaliana
-
 ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate Arabidopsis thaliana Col-0
-
 ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Arabidopsis thaliana Col-0
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-
root
-
 Arabidopsis thaliana
-
seed
-
 Arabidopsis thaliana
-
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1,3-bis(diphosphate) 2,4,5,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1,3-bis(diphosphate) 2,4,5,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1-triphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1-triphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate
-
 ?

Subunits

Subunits Comment Organism
More Vip1 domain organization Arabidopsis thaliana
More Vip2 domain organization Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
AtVip1
-
 Arabidopsis thaliana
AtVip2
-
 Arabidopsis thaliana
InsP6 kinase
-
 Arabidopsis thaliana
IP6K
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
additional information a small amount of InsP7 and InsP8 is accumulated in seeds of higher plants. Residue D292 of AtVIP1 is critical for activity of the kinase domain. The kinase domains alone does not show InsP7 synthesis activity to same levels as the intact AtVIP1 Arabidopsis thaliana
additional information a small amount of InsP7 and InsP8 is accumulated in seeds of higher plants. The kinase domains alone does not show InsP7 synthesis activity to same levels as the intact AtVIP2 Arabidopsis thaliana
physiological function isozymes AtVip1 and AtVip2 are differentially expressed in plant tissues, suggesting nonredundant or non-overlapping functions in plants. Both AtVip1 and AtVip2 encode proteins capable of restoring InsP7 synthesis in Saccharomyces cerevisiae mutants, AtVip1 and AtVip2 can function as bonafide InsP6 kinases. The plant paralogues of the yeast Vip genes can catalyze the synthesis of InsP7 and correct the phenotypic consequences of a yeast vip1 null mutation Arabidopsis thaliana
physiological function isozymes AtVip1 and AtVip2 are differentially expressed in plant tissues, suggesting nonredundant or non-overlapping functions in plants. Both AtVip1 and AtVip2 encode proteins capable of restoring InsP7 synthesis in yeast mutants, thus AtVip1 and AtVip2 can function as bonafide InsP6 kinases. The plant paralogues of the Saccharomyces cerevisiae Vip genes can catalyze the synthesis of InsP7 and correct the phenotypic consequences of a yeast vip1 null mutation Arabidopsis thaliana