Cloned (Comment) | Organism |
---|---|
recombinant co-overexpression of InsP6K2 and C-terminal residues 219-414 of TDP-43 from InsP6K2-pDsRed tag and TDP219-pEGFP tag plasmids in SHSY-5Y cells. Transfection of SHSY-5Y cells with a plasmid encoding a catalytically inactive, dominant-negative InsP6K2 (K2 K/A). HSP90 protein expression is reduced in the cytoplasmic fraction of TDP219- and InsP6K2-transfected cells. HSP90 expression is also significantly reduced in cells doubly transfected with TDP219M and InsP6K2 compared with control cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | enzyme InsP6K2 is translocated from the nucleus to the cytosol during apoptosis | Homo sapiens | 5829 | - |
nucleus | enzyme InsP6K2 is translocated from the nucleus to the cytosol during apoptosis | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UHH9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
anterior horn cell | spinal cord | Homo sapiens | - |
spinal cord | co-localization with phosphorylated TDP-43 of InsP6K2 in the cytoplasm of anterior horn cells of the spinal cord | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
inositol hexakisphosphate kinase type 2 | - |
Homo sapiens |
InsP6K2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme InsP6K2 is translocated from the nucleus to the cytosol during apoptosis | Homo sapiens |
physiological function | inositol hexakisphosphate kinase type 2 (InsP6K2), which converts inositol hexakisphosphate (InsP6) to InsP7, mediates cell death in mammalian cells. Cell death is augmented in the presence of cytoplasmic TDP-43 aggregations and activated InsP6K2, while cells with only cytoplasmic TDP-43 aggregation survive because Akt activity increases. Enzyme InsP6K2 causes neuronal cell death in patients suffering frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) or amyotrophic lateral sclerosis (ALS). InsP6K2 and cytoplasmic TDP-43 induce depletion of Akt phosphorylation and decrease casein kinase 2 | Homo sapiens |