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Literature summary for 2.7.4.21 extracted from

  • Ye, C.; Bandara, W.M.; Greenberg, M.L.
    Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae (2013), J. Biol. Chem., 288, 24898-24908.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q12494 gene KCS1
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Synonyms

Synonyms Comment Organism
Kcs1
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction deletion of KCS1, which blocks synthesis of inositol diphosphates on the 5-hydroxyl of the inositol ring, causes inositol auxotrophy and decreased intracellular inositol and phosphatidylinositol levels. These defects are caused by a profound decrease in transcription of INO1, which encodes myo-inositol-3-phosphate synthase. Expression of genes that function in glycolysis, transcription, and protein processing is not affected in kcs1DELTA. Deletion of OPI1, the INO1 transcription repressor, does not fully rescue INO1 expression in kcs1DELTA. Decreased inositol biosynthesis in kcs1DELTA is due to downregulation of INO1 transcription, but decreased inositol biosynthesis in kcs1DELTA is not because of perturbation of the UASINO regulatory complex Opi1-Ino2-Ino4, overview Saccharomyces cerevisiae
physiological function modulation of Kcs1 controls INO1 transcription by regulating synthesis of inositol diphosphates, model of regulation of INO1 transcription by Kcs1 and inositol diphosphates, overview. bZIP and inositol pyrophosphate kinase (DINS) domains of enzyme Kcs1 are required for INO1 transcription. The Kcs1 protein, but not transcription, is regulated in response to inositol Saccharomyces cerevisiae