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Literature summary for 2.7.4.21 extracted from

  • Azevedo, C.; Szijgyarto, Z.; Saiardi, A.
    The signaling role of inositol hexakisphosphate kinases (IP6Ks) (2011), Adv. Enzyme Regul., 51, 74-82.
    View publication on PubMed
Search for more literature for 2.7.4.21

Inhibitors

Inhibitors Comment Organism Structure
H2O2 H2O2 as low as 0.1 mM dramatically reduces enzymatic activity Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4
-
 ATP pH and temperature not specified in the publication Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate
-
 Rattus norvegicus ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?
additional information isoforms IP6K1 and IP6K2 bind to AP3B1protein Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase
-
 Rattus norvegicus
IP6K
-
 Rattus norvegicus
IP6K1 isoform Rattus norvegicus
IP6K2 isoform Rattus norvegicus
IP6K3 isoform Rattus norvegicus

General Information

General Information Comment Organism
malfunction deletion of isoform IP6K2 prevents the apoptotic actions of interferon beta and gamma-irradiation and cisplatin in different cancer cell lines Rattus norvegicus
physiological function isoform IP6K2 plays a specific role in regulating cell death. Isoform IP6K2 overexpression, that causes 10 to 20fold increase in IP7 level, enhances cell death Rattus norvegicus