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Literature summary for 2.7.4.21 extracted from

  • Nagata, E.; Luo, H.R.; Saiardi, A.; Bae, B.I.; Suzuki, N.; Snyder, S.H.
    Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death (2005), J. Biol. Chem., 280, 1634-1640.
    View publication on PubMed
Search for more literature for 2.7.4.21

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cells, PC12 cells, Jurkat T cells, OVCAR-3 cells, HL-60 cells and HEK-293 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
nucleus cytotoxicity is associated with a translocation of InsP6K2 from nuclei to mitochondria Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate Homo sapiens apoptosis regulation ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
OVCAR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate apoptosis regulation Homo sapiens ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase-2
-
 Homo sapiens
InsP6K2
-
 Homo sapiens