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Literature summary for 2.7.4.14 extracted from

  • Alexandre, J.A.; Roy, B.; Topalis, D.; Perigaud, C.; Deville-Bonne, D.
    Enantio-selectivity of human nucleoside monophosphate kinases (2007), Nucleosides Nucleotides Nucleic Acids, 26, 1375-1379.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
D-CMP pH 7.4, 37°C Homo sapiens
0.05
-
D-UMP pH 7.4, 37°C Homo sapiens
0.36
-
2'-azido-D-dCMP pH 7.4, 37°C Homo sapiens
0.7
-
L-dUMP pH 7.4, 37°C Homo sapiens
0.73
-
L-dCMP pH 7.4, 37°C Homo sapiens
0.75
-
L-CMP pH 7.4, 37°C Homo sapiens
0.9
-
2'-azido-D-dUMP pH 7.4, 37°C Homo sapiens
1
-
D-dCMP pH 7.4, 37°C Homo sapiens
1.2
-
2'-azido-L-dCMP pH 7.4, 37°C Homo sapiens
1.3
-
D-dUMP pH 7.4, 37°C Homo sapiens
1.3
-
2'-azido-L-dUMP pH 7.4, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + CMP Homo sapiens
-
ADP + CDP
-
?
ATP + dCMP Homo sapiens higher activity with the D-enantiomer compared to the L-enantiomer ADP + dCDP
-
?
ATP + dUMP Homo sapiens higher activity with the D-enantiomer compared to the L-enantiomer ADP + dUDP
-
?
ATP + UMP Homo sapiens
-
ADP + UDP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-azido-CMP 4fold higher activity with 2'-azido-dCMP than with 2'-azido-CMP Homo sapiens ADP + 2'-azido-CDP
-
?
ATP + 2'-azido-D-dCMP
-
Homo sapiens ADP + 2'-azido-D-dCDP
-
?
ATP + 2'-azido-D-dUMP
-
Homo sapiens ADP + 2'-azido-D-dUDP
-
?
ATP + 2'-azido-dCMP 4fold higher activity with 2'-azido-dCMP than with 2'-azido-CMP Homo sapiens ADP + 2'-azido-dCDP
-
?
ATP + 2'-azido-dUMP similar activity with 2'-azido-UMP and 2'-azido-dUMP Homo sapiens ADP + 2'-azido-dUDP
-
?
ATP + 2'-azido-L-dCMP
-
Homo sapiens ADP + 2'-azido-L-dCDP
-
?
ATP + 2'-azido-L-dUMP
-
Homo sapiens ADP + 2'-azido-L-dUDP
-
?
ATP + 2'-azido-UMP similar activity with 2'-azido-UMP and 2'-azido-dUMP Homo sapiens ADP + 2'-azido-UDP
-
?
ATP + CMP
-
Homo sapiens ADP + CDP
-
?
ATP + dCMP higher activity with the D-enantiomer compared to the L-enantiomer Homo sapiens ADP + dCDP
-
?
ATP + dUMP higher activity with the D-enantiomer compared to the L-enantiomer Homo sapiens ADP + dUDP
-
?
ATP + L-CMP
-
Homo sapiens ADP + L-CDP
-
?
ATP + L-dCMP
-
Homo sapiens ADP + L-dCDP
-
?
ATP + L-dUMP
-
Homo sapiens ADP + L-dUDP
-
?
ATP + UMP
-
Homo sapiens ADP + UDP
-
?
additional information the enzyme shows enantioselectivity, acceptor-binding site structure of human UMP-CMP kinase in the closed form or in ligand-bound forms, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
nucleoside monophosphate kinase
-
Homo sapiens
UMP-CMP kinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens