Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.4.14 extracted from

  • Topalis, D.; Kumamoto, H.; Alexandre, J.A.; Dugue, L.; Pochet, S.; Berteina-Raboin, S.; Agrofoglio, L.A.; Deville-Bonne, D.
    Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase (2007), Nucleosides Nucleotides Nucleic Acids, 26, 1369-1373.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + CMP Homo sapiens
-
ADP + CDP
-
?
ATP + dCMP Homo sapiens
-
ADP + dCDP
-
?
additional information Homo sapiens the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P30085
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CMP
-
Homo sapiens ADP + CDP
-
?
ATP + dCMP
-
Homo sapiens ADP + dCDP
-
?
additional information the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview Homo sapiens ?
-
?
additional information substrate/product binding site determination and kinetics using MABA-CDP in a competition assay, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
UMP-CMP kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens