Cloned (Comment) | Organism |
---|---|
transient expression of wild-type and mutant DCK/CMPK enzymes in COS-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | determination and analysis of 28 polymorphisms in DCK/CMPK enzymes, genotyping with humans of different ethnic origins, overview. Variant allozyme enzyme activities range from 32 to 105% of the wild-type enzyme for DCK and from 78 to 112% of wild-type enzyme for CMPK, with no significant differences in apparent Km values for either enzyme except for a DCK Val24/Ser122 double variant allozyme, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km values of mutant enzymes, overview | Homo sapiens | |
0.0146 | - |
gemcitabine | wild-type DCK | Homo sapiens | |
0.246 | - |
gemcitabine phosphate | wild-type CMPK | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30085 | African-American, Caucasian-American, Han Chinese-American, and Mexican-American subjects | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + gemcitabine | activity of DCK | Homo sapiens | ADP + gemcitabine monophosphate | i.e. 2',2'-difluorodeoxycytidine 5'-monophosphate | ? | |
ATP + gemcitabine phosphate | activity of CMPK | Homo sapiens | ADP + gemcitabine diphosphate | i.e. 2',2'-difluorodeoxycytidine 5'-diphosphate | ? |
Subunits | Comment | Organism |
---|---|---|
More | DCK and CMPK structural models from crystal structures, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CMPK | - |
Homo sapiens |
cytidine monophosphate kinase | - |
Homo sapiens |
dCK | - |
Homo sapiens |
deoxycytidine kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |