Application | Comment | Organism |
---|---|---|
medicine | screening of acyclic phosphonate analogs to find antimetabolites for antivirus and anticancer therapies | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression in Escherichia coli, wild type and selenomethionine labelled protein | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
of the selenomethionine labelled protein in complex with UMP, CMP, ADP, AMP-PCP, cidofovor and P1-(5-adenosyl) P5-(5-uridyl) pentaphosphate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-Br-uracil vinylphosphonate | - |
Homo sapiens | |
5-Cl-uracil vinylphosphonate | - |
Homo sapiens | |
5-F-Phe-uracil vinylphosphonate | - |
Homo sapiens | |
5-Phe-S-uracil vinylphosphonate | - |
Homo sapiens | |
5-Phe-uracil vinylphosphonate | - |
Homo sapiens | |
uracil vinylphosphonate | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
CMP | - |
Homo sapiens | |
0.13 | - |
UMP | - |
Homo sapiens | |
1 | - |
Cidofovir | - |
Homo sapiens | |
1.1 | - |
dCMP | - |
Homo sapiens | |
1.3 | - |
dUMP | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30085 | - |
- |
Purification (Comment) | Organism |
---|---|
of the recombinant protein | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine | Cidofovir | Homo sapiens | ADP + (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine | - |
? | |
ATP + CMP | - |
Homo sapiens | ADP + CDP | - |
? | |
ATP + dCMP | - |
Homo sapiens | ADP + dCDP | - |
? | |
ATP + dUMP | no activity with CDP, dTMP, AMP, GMP | Homo sapiens | ADP + dUDP | - |
? | |
ATP + UMP | - |
Homo sapiens | ADP + UDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytidylate kinase | - |
Homo sapiens |
UCK | - |
Homo sapiens |
UMP-CMP kinase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
5-Cl-uracil vinylphosphonate | - |
Homo sapiens | |
0.017 | - |
5-Br-uracil vinylphosphonate | - |
Homo sapiens | |
0.028 | - |
5-Phe-S-uracil vinylphosphonate | - |
Homo sapiens | |
0.7 | - |
uracil vinylphosphonate | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.03 | - |
- |
Homo sapiens | 5-Cl-uracil vinylphosphonate | |
0.035 | - |
- |
Homo sapiens | 5-Br-uracil vinylphosphonate | |
0.05 | - |
- |
Homo sapiens | 5-Phe-S-uracil vinylphosphonate | |
0.12 | - |
amplitude 50% | Homo sapiens | 5-Phe-S-uracil vinylphosphonate | |
0.23 | - |
- |
Homo sapiens | 5-F-Phe-uracil vinylphosphonate | |
1.2 | - |
- |
Homo sapiens | uracil vinylphosphonate |